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In the absence of 11β-HSD1 mice are more delicate to endotoxaemia (Zhang and Daynes 2007) acute irritation is extra severe (Coutinho et al. 2006) and pro-resolution mechanisms may be delayed (Gilmour et al. 2006).
We have lately found 11β-HSD1 expression and activity in mast cells key initiators of acute irritation and critical targets of the anti-inflammatory actions of glucocorticoids in allergy (Coutinho et al. 2006). Mast cells from 11β-HSD1-deficient mice are hypersensitive to degranulating stimuli (Coutinho et al. 2006) suggesting that endogenous glucocorticoid amplification by way of 11β-HSD1 restrains their exercise.
Dendritic cells are key antigen presenting cells that bridge the innate and adaptive immune techniques. Immature dendritic cells are activated when they seize course of then present antigens maturing into immunostimulatory cells in the course of. Activated dendritic cells migrate to draining lymph nodes the place they interact with naive T cells to instruct the adaptive
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Staci 时间: 06-04 03:25   主题:无标题
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The early research on steroids clearly confirmed that anabolic
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Nina 时间: 06-04 03:21   主题:无标题
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